HIGH FRUCTOSE INDUCED OSTEOGENIC DIFFERENTIATION OF HUMAN VALVE INTERSTITIAL CELLS VIA ACTIVATING PI3K/AKT/MITOCHONDRIA SIGNALING

High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K/AKT/mitochondria signaling

Background: Aortic valve stenosis (AS) is a common, lethal cardiovascular disease.There is no cure except the valve replacement at last stage.Therefore, an understanding of the detail mechanism LED Bulb is imperative to prevent and intervene AS.Metabolic syndrome (MetS) is one of the major risk factors of AS whereas fructose overconsuming tops the

read more

Clinicopathological and Molecular Investigation of Newcastle Disease Outbreaks in Vaccinated and Non-Vaccinated Broiler Chicken Flocks in Nepal

Newcastle disease (ND) is a highly contagious viral disease caused by the paramyxovirus, which is a single-stranded ribonucleic acid (RNA) virus.This study was conducted to investigate ND outbreaks in 10 vaccinated or non-vaccinated broiler farms, collectively housing 9840 birds of various ages in the Chitwan and Nawalpur districts of Nepal from Ju

read more

Epidemiology of major lower limb amputation using routinely collected electronic health data in the UK: a systematic review protocol

Introduction It is estimated that peripheral arterial disease occurs in one in five people aged over 60 years in the UK.Major lower Shirt limb amputation is a debilitating and life-changing potential outcome of peripheral arterial disease.A number of risk factors are involved in the development of the disease including smoking and diabetes.There is

read more


Effects of meteorological conditions on brood care in cooperatively breeding carrion crow and consequences on reproductive success

Abstract Meteorological stressors (e.g., temperature and rain shortage) constrain brood provisioning in some bird species, but the consequences on reproductive success have been rarely quantified.Here we show, in a cooperatively breeding population of carrion crow Corvus corone in Vinyl Record Cleaner Spain, that individual feeding rates decreased

read more